Posted by bleauberry on March 30, 2019, at 10:46:36
In reply to Study said amitriptyline most effective?, posted by mtom on March 29, 2019, at 11:48:52
These kinds of studies are not reliable for individual prognosis.
For one thing, the studies are flawed. Each one has its own flaws, depending on who paid for it, who the sponsors were, how the patients were screened, how the data was gathered, how the data was interrupted. There is a great deal of human error, both purposeful and accidental, in all of that.
Amytrip has some of the harshest side effects for most people. It does not restore anybody to the person they used to be.
In these studies, they judge something as "statistically significant" but that doesn't mean it is "actually significant". For example a study may show that Paxil is statistically significantly more effective than placebo, except when you look at the detailed numbers, which are usually hidden, you find that 50% of people on placebo improved a little bit, not a lot, and that 56% of med people improved a little bit, not a lot. 50% versus 56% is statistically significant. But in the real world, that is not significant. So these studies have a way of producing fake pictures in your mind based on twisted numbers games. In those same Paxil studies, 3 patients committed suicide during the study. They don't mention that part.
I saw a study once that said Prozac plus Zyprexa increased serotonin, norepinephrine, and dopamine dramatically in the brain, more than any other cocktail, and was good for treatment resistant depression. Despite what I just said above about the flaws of these studies, there was enough there that I wanted to find out for myself. So I did. And that combo ended up being better than any other combo I ever tried.
So sometimes we have to just go by our instincts.
poster:bleauberry
thread:1103744
URL: http://www.dr-bob.org/babble/20190206/msgs/1103764.html