Posted by Christ_empowered on February 25, 2019, at 10:20:27
In reply to Re: neuroleptic dosage » Christ_empowered, posted by beckett2 on February 24, 2019, at 18:08:04
hi. thanks for your reply.
"tardive psychosis" is what happens when long term neuroleptic treatment makes psychosis more prominent or...in some cases...leaves the person with psychotic symptoms for the 1st time, whereas they were absent before such treatment (example: neuroleptics were once popular for agitated, non psychotic depression...and some of those patients went on to develop psychotic symptoms).
-some- researchers have speculated that using anti-seizure drugs somehow "helps" both prevent and manage tardive psychosis. i vaguely recall reading that animal models showed that abilify (aripiprazole) causes less D2 upregulation than most neuroleptics. That's good....but, of course, that's in animals, and its just using Abilify, by itself. no word yet on what abilify in the context of multi-drug cocktails does to those D2 receptors.
anyway, more to the point, there's also limited data showing that lamictal with neuroleptics does...something, somehow...so there's less D2 upregulation. the idea is: all neuroleptics block D2 receptors. As the brain adapts, the brain becomes -more- sensitive to dopamine, not less. that's just -1- problem associated w/ neuroleptic treatment, btw.
so...then, when if the neuroleptic is reduced or stopped, the sensitized brain gets hit with dopamine, psychosis ensues, then the person is often re-medicated, often at a higher dose of neuroleptic, with this "relapse" offering "proof" that they needed the neruoleptic in the 1st place.
blah. anwyay...again, thanks for your reply. :-)
poster:Christ_empowered
thread:1103342
URL: http://www.dr-bob.org/babble/20190206/msgs/1103395.html