Posted by bleauberry on June 27, 2018, at 6:43:06
In reply to any drugs with strong NRI action ?, posted by TriedEveryMedication on June 25, 2018, at 14:59:48
Savella = Milnacipran. 1 part serotonin 3 parts norepinephrine. Feels sort of Ritalin-like. Studies suggest its effects are similar to Ritalin. Savella was actually the best prescription or overseas antidepressant I ever experienced in my 20 years of taking all these drugs. Nortrip, Desip, Protrip - none of these come anywhere close to Savella in terms of mood boost or ADHD management.
> my adhd-pi seems to respond to NRIs, especially desipramine.
>
> I've tried atomoxetine which I've seen marketed as a "safer desipramine", but it just doesn't work as well.
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> the Ki for atomoextine for NET is 5 and for desipramine is like 0.2. (lower the constant, the greater the affinity)
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> reboxetine isn't available in the US and its binding profile with NET is 13, weaker than atomoxetine.
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> I guess Protriptyline is an option, its Ki is 1.4. still weaker than desipramine, though.
>
>
poster:bleauberry
thread:1099300
URL: http://www.dr-bob.org/babble/20180521/msgs/1099312.html