Posted by linkadge on June 25, 2018, at 15:40:10
In reply to any drugs with strong NRI action ?, posted by TriedEveryMedication on June 25, 2018, at 14:59:48
The Ki doesn't matter that much.
The ki just tells the drug's effect at a certain concentration. The concentration is a function of the metabolism of the drug and the dose.
In other words, with perhaps a higher dose of protriptyline, you are going to get the same NRI effect.
You may not need a higher dose, however, if protriptyline is better absorbed, or has a longer half life.
Linkadge
poster:linkadge
thread:1099300
URL: http://www.dr-bob.org/babble/20180521/msgs/1099301.html