Posted by linkadge on April 21, 2018, at 9:07:10
In reply to TRIP8b inhibitors? Truly novel antidepressants., posted by SLS on April 21, 2018, at 6:31:42
TRIP8b inhibitors apparently exert their effect through HCN1 channels (no expert here, just google searches).
Ketamine inhibits HCN1. Zinc may also interact with both HCN channels and TRIP8b.
Keep in mind though, that this is the stress induced model of depression. While most people will experience some degree of depression if subjected to enough stress, not all depressive disorders are a result of external stress.
Some researchers argue that focusing on the stress model of depression may be ignoring the underlying cause of a significant group of patients.
Linkadge
poster:linkadge
thread:1098278
URL: http://www.dr-bob.org/babble/20180331/msgs/1098282.html