Posted by SLS on April 21, 2018, at 6:31:42
A novel set of antidepressant drugs might be developed that inhibit the actions of TRIP8b. This protein acts during times of stress to suppress activity in the hippocampus via the entorhinal cortex, which is located upstream. The hippocampus is a brain structure involved in mood and memory. When TRIP8b is inhibited, both of these regions become more active. In the laboratory, TRIP8b knock-out mice demonstrated antidepressant behavior and memory-enhancement. I couldn't guess at how long it would take for such compounds to become available - if at all. Some of us will never see them, but our children might.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1098278
URL: http://www.dr-bob.org/babble/20180331/msgs/1098278.html