Posted by beckett2 on April 5, 2018, at 18:30:30
In reply to Re: Tianeptine » beckett2, posted by SLS on April 5, 2018, at 14:39:28
Hello Scott,
>
> Perhaps you can add Cymbalta (duloxetine) first and then taper the Ultram (tramadol) afterwards. Both Cymbalta and Ultram are SNRI, and I would hope that the presence of Cymbalta will reduce the SNRI component of Ultram withdrawal. Serotonin syndrome? I don't know. Lots of people take two SRIs at the same time. The Ki of Ultram for the SERT (serotonin transporter) is moderate at best - 1000.00. With Cymbalta, it is 0.50. The lower the number, the stronger the binding affinity.Good advice. My concern is covering the opioid effect as well. Not sure how that might play out.
> > The relief from Cymbalta was striking.>In what ways?
Neuropathic pain and fibromyalgiac pain. That free floating always pain, I think, allodynia.
>
> What did Cymbalta do to you?Reduced background pain-noise.
> What do you take Ultram for?For the same effect. Works for neuropathic pain. I had a series of trials for pain relief, and Tramadol worked. Ah. In addition, my mood was positively affected. In fact, (as my doc as prescribed), if I take an additional tablet, which I occasionally do, I perk right up. Of course, if I did this often, this would no longer happen.
>You don't have chronic pain, do you? And have you taken Tramadol or cymbalta?
poster:beckett2
thread:1097839
URL: http://www.dr-bob.org/babble/20180331/msgs/1097998.html