> > > I'd love to get off Ultram, but that seems insurmountable.
> > Have you tried Cymbalta?
> Good morning!
>
> Would there be some way to move from one to the other to lessen withdrawals? (I realize Ultram is an opioid.)
Perhaps you can add Cymbalta (duloxetine) first and then taper the Ultram (tramadol) afterwards. Both Cymbalta and Ultram are SNRI, and I would hope that the presence of Cymbalta will reduce the SNRI component of Ultram withdrawal. Serotonin syndrome? I don't know. Lots of people take two SRIs at the same time. The Ki of Ultram for the SERT (serotonin transporter) is moderate at best - 1000.00. With Cymbalta, it is 0.50. The lower the number, the stronger the binding affinity.
> The relief from Cymbalta was striking.
In what ways?
> At the time I didn't understand one could take zofran (like I do now). Most days I'd be doubled over on the bed.
What did Cymbalta do to you?
What do you take Ultram for?
- Scott
![[collapse]](http://www.dr-bob.org/images/babble/hide.gif)
this signature | Show by default | Change to hide (next time)Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw