Posted by SLS on November 4, 2017, at 12:15:22
In reply to Re: I have only been psychotic on Nardil. Never withou » SLS, posted by linkadge on November 4, 2017, at 10:03:41
Your suggestion makes sense.
I just spoke to a friend of mine who discontinued Seroquel 800 mg/day. It took two months for her to taper.
- Scott> Again, I have no data on how long one would need to withdraw from Seroquel.
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> Supposedly Seroquel leads to less d2 receptor up regulation, owing to its 'loose binding' to the d2 receptor. So, perhaps dopamine supersensitivty rebound is less of an issue. The issue with Seroquel, however, is that it can be effective for treating a variety of nonpsychotic illnesses as well (i.e. depression, gad, etc). So, while one might not need it for psychosis, there is a possibility that reducing it would lead to a worsening of other conditions.
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> The benefit of Seroquel, is that a therapeutic dose (say of 600mg) can be divided into 24x25mg. So, one could reduce by say 25mg a week over about half a year (of course, stopping, or taking longer if needed).
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> The problem with olanzapine, is that 20mg can be divided into 8x2.5mg, allowing for fewer increments of the taper. Of course, the 2.5mg could be split.
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> If somebody was to decrease Seroquel by 25mg a week. It would be less likely (IMHO) of a shock to the system or sudden relapse. Of course, it probably benefits to have a friend or family member keep an eye out, in case one is not able to recognize a return of symptoms.
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> Again, just thoughts.
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> Linkadge
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Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1095680
URL: http://www.dr-bob.org/babble/20161215/msgs/1095729.html