Posted by cakethread on October 22, 2016, at 0:27:03
In reply to Re: managing desipramine insomnia - again. » TriedEveryMedication, posted by SLS on October 18, 2016, at 7:16:21
> > Actually instead of clonidine (alpha-1) my doc gave me prazosin (alpha-2) to take with the desipramine at night.
>
> Prazosin is a NE alpha-1a/b/d receptor blocker that can be taken all day long (t.i.d.) at 30-40 mg/day without blocking the therapeutic effects of desipramine or producing sedation. It is extremely clean except for its tendency to reduce sex-drive. Prazosin can produce dizziness early in treatment, but it usually disappears.
>
> I am going to assume that you already tried nortriptyline.
>
>
> - ScottHey,
I'm curious how this works. Isn't the primary mechanism of action of desipramine as a norepinephrine re-uptake inhibitor? In that case, wouldn't blocking alpha receptor subtypes have a cancellative effect?
poster:cakethread
thread:1090062
URL: http://www.dr-bob.org/babble/20160928/msgs/1092713.html