Posted by TriedEveryMedication on October 18, 2016, at 5:38:31
In reply to Re: managing desipramine insomnia - again., posted by linkadge on July 1, 2016, at 13:15:25
> Hmm. Possibly clonidine?
>
> Clonidine alone is useful for ADHD (as well as some use in anxiety and insomnia). It actually lowers norepinephrine (temporarily) by activating norepinephrine feedback autoreceptors.
>
> Because it has a shorter half life, it might be useful in temporarily lowering norepinephrine release during sleep time.
>
> Cyproheptadine might also be worth a try.
>
> Linkadge
>
>So I finally got around to trying this. Actually instead of clonidine (alpha-1) my doc gave me prazosin (alpha-2) to take with the desipramine at night.
Sure enough it works magic on the desipramine-induced insomnia. Haven't taken it long enough to see if it will interfere with the benefits of the desipramine during the day - hopefully not.
Thanks for a great idea.
poster:TriedEveryMedication
thread:1090062
URL: http://www.dr-bob.org/babble/20160928/msgs/1092651.html