Posted by Hello321 on August 3, 2016, at 17:25:16
In reply to Re: orthomolecular, posted by SLS on August 3, 2016, at 1:09:09
I had figured it was either periactins 2a or 2c action. Particularly its 2c inverse agonism. I think the inverse agonism, as opposed to just typical antagonism at that receptor that really made the difference. Im in the process of trying to get the new med known as Nuplazid. My pdoc prescribed it last week and im hoping to get on its patient assistance program, because at the pharmacy it is over $1,000 for a 30 day supply. But its strong inverse agonism at the 2a and 2c receptor makes me hopeful it might do the trick.
With cyproheptadine, a dose of it would stop working after just a few days. Id raise the dose and get more benefit. Over time as i did this i slowly went from having severe anhedonia to feeling so much better. But i eventually got to too high a dose and had to stop taking it. That was 5 years ago and since then anhedonia has very slowly crept back up over this time. Ive tried it again at normal doses recently and it still wont work for me. But i do believe Nuplazid is much stronger at the 2a/2c receptor. So maybe i can work something out with it.
poster:Hello321
thread:1090994
URL: http://www.dr-bob.org/babble/20160713/msgs/1091140.html