Re: Do Z-Drugs cause tolerance to benzos? » Horse

Posted by SLS on July 23, 2016, at 11:16:52

In reply to Re: Do Z-Drugs cause tolerance to benzos? » regisx, posted by Horse on July 22, 2016, at 22:36:46

> The short answer is yes, and I agree that it does suck. I've found there's really no free lunch.
> > Z-drugs also work on Gaba receptors. I don't know if they hit the same receptors as benzos like xanax or ativan. Does anybody know this?
> >
> > Does this mean if you regularly take z-drugs benzos won't work for you anymore or at least not as good as they used to?
> >
> > This would really suck.
I think there would be cross-tolerance to the hypnotic effects of Z-drugs and BZDs, but not to the anxiolytic effects of the BZDs. This is the result of the drugs binding to different subunits of the GABA-A receptor.
1. alpha-1 subunit is associated with sedation and hypnotic effects.
2. alpha-2 and alpha-3 subunits are involved in anxiolytic effects.
BZD = #1 + #2
Z-Drugs = #1 only

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Thread

Do Z-Drugs cause tolerance to benzos? regisx 7/22/16
Re: Do Z-Drugs cause tolerance to benzos? » regisx Horse 7/22/16
Re: Do Z-Drugs cause tolerance to benzos? » Horse SLS 7/23/16
Re: Do Z-Drugs cause tolerance to benzos? jonhed 7/23/16
Re: Do Z-Drugs cause tolerance to benzos? regisx 7/23/16
Re: Do Z-Drugs cause tolerance to benzos? jonhed 7/24/16
Re: Do Z-Drugs cause tolerance to benzos? regisx 7/24/16
Re: Do Z-Drugs cause tolerance to benzos? jonhed 7/25/16

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