Re: Venlafaxin mode of action? » Lamdage22

Posted by TriedEveryMedication on June 4, 2016, at 11:32:21

In reply to Venlafaxin mode of action?, posted by Lamdage22 on May 9, 2016, at 7:18:41

> So Venlafaxine is partially effective for me. Is this to be explained solely by Serotonin/Noradrenalin reuptake inhibition or does Venlafaxin have any other actions?
venlaxfaxine has strong SERT binding affinity, weaker NET binding affinity, and then very weak affinities for a whole ton of other things.
(note that with Ki values, the lower the number the stronger the affinity)
here is a list of binding affinities discovered. I limited it to Ki of 2000:
http://kidbdev.med.unc.edu/databases/pdsp.php?knowID=0&kiKey=&receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testDDRadio=testDDRadio&testLigandDD=2692&testLigand=&referenceDD=&reference=&KiGreater=&kiLessRadio=less&KiLess=2000&doQuery=Submit+Query

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Venlafaxin mode of action? Lamdage22 5/9/16
Re: Venlafaxin mode of action? SLS 5/9/16
Re: Venlafaxin mode of action? Lamdage22 5/9/16
Viibryd Lamdage22 5/9/16
Re: Viibryd » Lamdage22 J Kelly 5/9/16
Re: Venlafaxin mode of action? » Lamdage22 TriedEveryMedication 5/9/16
Re: Venlafaxin mode of action? SLS 5/9/16
Re: Venlafaxin mode of action? Lamdage22 5/10/16
Re: Venlafaxin mode of action? SLS 5/10/16
Re: Venlafaxin mode of action? Lamdage22 5/10/16
Re: Venlafaxin mode of action? linkadge 5/13/16
Re: Venlafaxin mode of action? » Lamdage22 TriedEveryMedication 6/4/16

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