Posted by SLS on May 15, 2016, at 7:14:01
In reply to Genetic interactions with Selegiline (Warrior gene, posted by Axmann on May 14, 2016, at 16:51:25
For depression, it is MAO-A inhibition that is most important in the therapeutic action of MAOIs. You can block 90% of MAO-A and be perfectly safe. Some people will go up to 120 mg/day of Nardil.
If you want the Emsam version of selegiline to work as an antidepressant, the minimum dosage is 9 mg/24. Even 6 mg/24 inhibits MAO-A to some extent.
- Scott----------------------------------------------
"CLINICAL PHARMACOLOGY
Pharmacodynamics
Selegiline (the drug substance of EMSAM) is an irreversible inhibitor of monoamine oxidase (MAO),
an intracellular enzyme associated with the outer membrane of mitochondria. MAO exists as two
isoenzymes, referred to as MAO-A and MAO-B. Selegiline has a greater affinity for MAO-B,
compared to MAO-A. However, at antidepressant doses, selegiline inhibits both isoenzymes (see
below).
The mechanism of action of EMSAM as an antidepressant is not fully understood, but is presumed to
be linked to potentiation of monoamine neurotransmitter activity in the central nervous system (CNS)
resulting from its inhibition of MAO activity. In an in vivo animal model used to test for
antidepressant activity (Forced Swim Test), selegiline administered by transdermal patch exhibited
antidepressant properties only at doses that inhibited both MAO-A and MAO-B activity in the brain.
In the CNS, MAO-A and MAO-B play important roles in the catabolism of neurotransmitter amines
such as norepinephrine, dopamine, and serotonin, as well as neuromodulators such as
phenylethylamine."
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1088953
URL: http://www.dr-bob.org/babble/20160501/msgs/1088972.html