Posted by J Kelly on May 15, 2016, at 5:44:00
In reply to Genetic interactions with Selegiline (Warrior gene, posted by Axmann on May 14, 2016, at 16:51:25
> It's very likely that I have the three-repeats variant of the MAO-A gene. (rs909525), which I believe means I have less activity of MAO-A
>
> I'm currently on selegiline 6 mg, and I was wanting to increase it to 9 mg.
>
> Is this safe to do, even though my MAO-A activity may already be low?
>I don't know anything about selegine so all I have to offer is my own experience. In addition, I've noted two things. First, that you have tried Parnate with good effect but poor sleep patterns, and second, the "warrior" gene can cause aggression and I would imagine other symptoms common to the aggressive state.
To have to abandon a good outcome due to poor sleep seems a shame. Would you be willing to try an AAP like Seroquel or Zyprexa with Parnate? Both are excellent sleep aids in my experience and may very well be effective treatments for symptoms relating to the MAO-A gene. Just a guess though.
> I do have ADHD-PI, dysthymia/depression, and
social anxiety.I did well on Emsam but kept having to increase the dose so ultimately I switched to Parnate which worked well for me at doses below 80mg.
I find Nardil to be much smoother and more mellow than Parnate. It's also VERY effective for depression and social anxiety *for me*.
I'm not sure any of this helps you as your question was Selegine.
Good luck,
Jade
poster:J Kelly
thread:1088953
URL: http://www.dr-bob.org/babble/20160501/msgs/1088967.html