Posted by SLS on May 14, 2016, at 6:13:43
In reply to Re: Why don't my meds work anymore/make me feel bad?, posted by Hello321 on May 12, 2016, at 22:06:19
> Over time these meds can make your brain less sensitive to the neurotransmitters they originally increase. Your brain tries to maintain homeostasis, and when it sees the meds doing all the work, your brain is in an even less "healthy" state because of the med. Ive experienced it. Some peoples brains seem to bounce back after these meds screw with them. Some brains just don't.
Nice explanation. I totally agree with this.
> I think a med called Cyproheptadine worked great to help my brain recover after chronically taking adderall.
What things did you experience with Adderall that cyproheptadine was able to reverse?
> If you look at the way it works, it's not really clear why it would help at all with this. But if you read into the receptors it blocks off,particularly the 5ht2c receptor, which Cyproheptadine shuts off all activity of that receptor with its inverse Agonism. The 5ht2c receptor in your brain inhibits dopamine release. When it's blocked off, your brain is more free to release dopamine.
That is an interesting explanation. Do you think cyproheptadine would act similarly in cases of treatment-resistant depression or after exposure to multiple antidepressants? Perhaps it can be taken for a short period of time to reset important homeostatic dynamics. What were the side effects of cyproheptadine? Sedation or sleepiness?
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1088876
URL: http://www.dr-bob.org/babble/20160501/msgs/1088940.html