Posted by Hello321 on August 24, 2015, at 13:47:48
In reply to Re: Flibanserin or the 'pink pill' » Hello321, posted by phidippus on August 23, 2015, at 19:12:20
> What's your current regimen?
>
> I'm pretty skeptical about Flibanserin. I don't think libido is governed by 5ht receptors, as is evident by the efficacy of Cyproheptadine, which is a serotonin blocker.
>
> EricIm currently taking Viibryd and Adderall. Just started taking the Viibryd, so no effect from it yet.
And im not sure i get any benefit from Adderall anymore.But, im pretty certain my serotonin receptors have played a major role in my libido and condition on a whole. Cyproheptadine is the only med that has ever truly benefitted me. It brought me from being catatonic and with zero libido to being able to live a mostly normal life with a sex drive, until it stopped working. And my experience with Buspar, it actually had a negative effect on my libido, while many people experience improvement in that area with Buspar. And it is said this effect is from the 5ht1a partial agonism at the postsynaptic receptor, which when stimulated, results in an increase in dopamine release. But i believe Buspar had a negative effect on me with its stimulation at the presynaptic receptor, where i do believe it is a full agonist. Im pretty sute the presynaptic receptor causes a decrease in dopamine release, and that it had too little effect at my postsynaptic receptor.
And when it comes to Cyproheptadine,i believe its inverse agonism at the 5ht2c receptor brought all my pleasurable emotions back. This receptor inhibits dopamine, but when blocked, your brain is more free to react to pleasure by releasing dopamine.
So.... i wouldnt be too skeptical about the serotonin receptors having control over libido. And i think Flibanserin would be worth a try for libido and mood problems.
poster:Hello321
thread:1081532
URL: http://www.dr-bob.org/babble/20150806/msgs/1081699.html