Posted by ed_uk2010 on January 26, 2015, at 11:48:03
In reply to Re: Multiple mechanism with Zyprexa and some atyp, posted by Lamdage22 on January 26, 2015, at 10:58:56
>What would you recommend for my insomnia, ed?
Initially, I'd suggest that you try taking more Seroquel in the evening and less during the day, rather than adding more medication. I'm unsure of the value or safety of adding a third antipsychotic acting on some of the same receptors which are already blocked by your current high dose antipsychotic treatment.
The thing is about adding pipamperone.... low dose mainly block 5-HT2a receptors, high doses block D2 receptors as well. I imagine your 5-HT2a receptors are substantially blocked already by Seroquel and Zyprexa. I don't think the TD risk or the diabetes risk of pipamperone are well known. Pipamperone is usually classified as a typical antipsychotic but its receptor binding profile is slightly atypical, despite its chemical similarity to haloperidol (Haldol).
How bad is your insomnia? Perhaps it would improve on treating your depression.
Have you struggled to find a suitable treatment for depression? You seem to be on a very small dose of venlafaxine. Do you have a history of symptoms being worsened by antidepressants eg. a manic episode being induced?
poster:ed_uk2010
thread:1074889
URL: http://www.dr-bob.org/babble/20150102/msgs/1075596.html