Posted by linkadge on December 14, 2014, at 20:12:40
In reply to Re: Caution » linkadge, posted by ed_uk2010 on December 13, 2014, at 10:49:42
Hi Ed,
I actually prefer a pure anticholinergic to something like amitriptyline. Amitriptyline is a good medication, but it really whacks you out (antihistamine + anticholinergic + all the rest).
I think its the M1 receptors that exert inhibitory control over the mesolimbic dopaminergic system. Mice lacking the M1 receptors display a depression resistant phenotype. The M1 receptors are important the consolation of emotional memory. For instance, blocking the m1 receptors will prevent the enhanced REM response in mice to predator exposure - as well as subsequent emotional disturbance.
AFAIK, Cogentin (benztropine) is also a dopamine reuptake inhibitor, which probably contributes to its abuse liability.
poster:linkadge
thread:1074099
URL: http://www.dr-bob.org/babble/20141120/msgs/1074218.html