Posted by ed_uk2010 on December 13, 2014, at 6:18:38
In reply to Re: Caution » linkadge, posted by SLS on December 12, 2014, at 20:35:09
>I remember arguing with you about nicotine many years ago.
Interesting that bupropion (Wellbutrin, Zyban) binds to certain nicotinic receptors, I believe as an antagonist but not at all nicotinic receptor subtypes. Another 'anti smoking' drug, varenicline (Champix, Chantix), a nicotinic partial agonist, has been associated with possibly inducing psychiatric disturbances including depression. Having said that, so has bupropion and so have most common ADs. Nothing is simple...
>HNK and alpha-7 nicotinic receptors:
>
> "A compound, hydroxynorketamine (HNK), has been identified by researchers that may treat symptoms of depression just as effectively and rapidly as ketamine, without the unwanted side effects associated with the psychoactive drug, according to a study.Very interesting, thanks for the link.
>Perhaps NMDA receptor blockade is not the mechanism by which ketamine produces antidepressant effects. That would be very convenient.
NMDA antagonists confuse me. I mean, memantine is used to treat Alzheimer's... and then other NMDA antagonists are dissociatives. I suppose most of them have a variety of neuropharmacological actions.
poster:ed_uk2010
thread:1074099
URL: http://www.dr-bob.org/babble/20141120/msgs/1074193.html