Posted by phidippus on November 11, 2014, at 16:46:36
In reply to Re: Campral: NMDA antagonist, Glutamate Modulator... » phidippus, posted by mogger on November 11, 2014, at 16:21:39
>riluzole was a combination of glutamate modulation and riluzole being a strongish NMDA antagonist
Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons. Riluzole has also been reported to directly inhibit the kainate and NMDA receptors, however this property has not been confirmed. The action of riluzole on glutamate receptors has been controversial, as no binding of the drug to any known sites has been shown for them. In addition, as its antiglutamatergic action is still detectable in the presence of sodium channel blockers, it is also uncertain whether or not it acts via this way. Rather, its ability to stimulate glutamate uptake seems to mediate many of its effects. In addition to its role in accelerating glutamate clearance from the synapse, Riluzole may also prevent glutamate release from presynaptic terminals. These effects combined could significantly reduce glutamate signaling and cause indirect antagonism without acting at glutamate receptors themselves.
>Wouldn't I have to vome off buspar too for Brintellix?
No. Buspar is just a partial agonist of the 5ht1a receptor. If anything it will act synergistically with the Brintellix.
>Why did you discontinue?
I didn't. I still take 1000 mg a day.
Depression doesn't happen all that often with Keppra.
Besides you're on so many ADs(lithium, lamictal, zoloft, mirtazapine, buspar...geez) I find it hard to believe it would make you depressed
Eric
poster:phidippus
thread:1073254
URL: http://www.dr-bob.org/babble/20141017/msgs/1073375.html