Posted by SLS on October 16, 2014, at 8:34:19
In reply to Re: Bad reactions to all antidepressants? » ed_uk2010, posted by BusuB on October 14, 2014, at 17:39:14
Have you tried imipramine? It is a tricyclic antidepressant for which there is a great deal of evidence as being effective in treating Panic Disorder with or without agoraphobia. Nortriptyine, desipramine, and clomipramine are said to be effecive, too, but have not been studied as thoroughly. At least on study showed clomipramine to be more effective than imipramine. Most people find the anti-cholinergic/pro-adrenergic side effects of tricyclics to be problematic, but you might find them tolerable. These effects are milder with nortriptyline and desipramine, but I don't know how they compare to imipramine therapeutically. The blood levels of imipramine found to be effective are between 110-140 ng/ml. Desipramine might be the logical choice, though, if serotoninergic effects are the cause of your intolerance of other antidepressants. Desipramine is the major active metabolite of imipramine, and is devoid of serotonin reuptake inhibition.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072226
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