Posted by ed_uk2010 on October 14, 2014, at 16:34:27
In reply to Bad reactions to all antidepressants?, posted by BusuB on October 14, 2014, at 12:50:37
Have you tried an antidepressant with a completely different mechanism of action, eg. mirtazapine? That would seem like a sensible first-choice if you've not already tried it. Mirtazapine can cause drowsiness and sometimes weight gain. Serious side effects are rare.
All the meds you've tried already are potent serotonin reuptake inhibitors. Some people develop physical restlessness on all SRIs, and do better on ADs which lack this property, on share it only to a minor extent.
Also, have you tried a less sedating, less-serotonergic tricyclic instead of clomipramine? Nortriptyline might be a good choice... if not, imipramine might help. Among the TCAs, genital numbing is only likely with clomipramine.
Finally, is your diagnosis major depression rather than something else such as bipolar disorder. That would affect treatment choice.
poster:ed_uk2010
thread:1072226
URL: http://www.dr-bob.org/babble/20140914/msgs/1072228.html