Posted by SLS on October 12, 2014, at 9:45:10
In reply to Re: viibryd -- and SLS, are you out there? :), posted by LouisianaSportsman on October 11, 2014, at 21:37:03
> If you suffered GI effects on vilazodone, Id caution a trial of vortioxetine [Brintellix]. Vortioxetine is purported to have stronger GI effects; also, it seems prone to initiate hypomania. (Caution for those with bipolar depression and those on concomitant bupropion therapy since bupropion increases mean plasma concentration of vortioxetine due to a metabolic interaction with a liver enzyme.)
>
> I would go an alternative route due to your failure with vilazodone.
>
> Minocycline has strong evidence for the treatment of schizophrenia, and it has neuroprotective properties that may make it efficacious for the off-label treatment of other psychiatric disorders.I responded pretty well to the addition of minocycline to my treatment regime. It gave me more mental energy and reduced cognitive impairments. From what I understand, it works better with antiglutamatergic drugs like lamotrigine (Lamictal) and N-acetylcysteine (NAC). I stopped taking it after two years because I developed a darkening of the skin on my feet and shins. There are some reports indicting that adding 1000 - 2000mg/day of vitamin C (ascorbic acid) helps to prevent hyperpigmentation. I wish I had known that in advance. Unfortunately, I haven't seen anything that would lead me to believe that vitamin C would increase the rate of fading of the discolorations once you have them. They usually fade once minocycline is discontinued, but it can take a year for them to disappear.
Where can I find information regarding the rate of mania as a treatment-emergent event with vortioxetine?
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072031
URL: http://www.dr-bob.org/babble/20140914/msgs/1072138.html