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Re: viibryd -- and SLS, are you out there? :) » joe f

Posted by SLS on October 10, 2014, at 18:26:25

In reply to Re: viibryd -- and SLS, are you out there? :), posted by joe f on October 10, 2014, at 13:34:23

> how do you know its 30 times more potent than Prozac-a pretty bold statement--then that would send you through the roof with anxiety

Hi Joe.

Here are a few things that I was able to find regarding vilazodone (Viibryd):


- Scott

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"In the rat cerebral cortex vilazodone inhibited serotonin reuptake 30 times more than fluoxetine"

http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CCQQFjAB&url=http%3A%2F%2Fwww.dovepress.com%2Fgetfile.php%3FfileID%3D12367&ei=WmA4VMS_N9GNyAT5kIHYCQ&usg=AFQjCNGkr6zsZElcRVIgWu9GrQsZWWWfXg&sig2=QJWydCGXLTuI0cj2elxvXQ&bvm=bv.77161500,d.aWw&cad=rja

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"Although vilazodones selectivity for serotonin reuptake inhibition relative to norepinephrine or dopamine reuptake inhibition is comparable to that of the SSRI fluoxetine, its potency for serotonin reuptake inhibition is 30-fold greater."

http://www.psychiatrist.com/_layouts/PPP.Psych.Controls/ArticleViewer.ashx?ArticleURL=/JCP/article/Pages/2011/v72n04/v72n0402.aspx

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"Results: Vilazodone inhibited serotonin reuptake into rat brain synaptosomes with an IC50 of 0.2 nM, which was 30-fold more potent than that of fluoxetine (IC50=6 nM)."

http://www.sec.gov/Archives/edgar/data/716646/000095012310052757/b81084exv99w6.htm

Refer to:

Kehne JH, Bartoszyk GD, Greiner HE, et al. In vitro characterization of vilazodone as a dual-acting serotonin reuptake receptor and 5-HT1A receptor partial agonist. Poster presented at: 65th Annual Meeting of the Society of Biological Psychiatry Meeting; May 2010; New Orleans, LA.

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Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1072031
URL: http://www.dr-bob.org/babble/20140914/msgs/1072082.html