Posted by SLS on October 10, 2014, at 18:26:25
In reply to Re: viibryd -- and SLS, are you out there? :), posted by joe f on October 10, 2014, at 13:34:23
> how do you know its 30 times more potent than Prozac-a pretty bold statement--then that would send you through the roof with anxiety
Hi Joe.
Here are a few things that I was able to find regarding vilazodone (Viibryd):
- Scott-----------------------------------------------
"In the rat cerebral cortex vilazodone inhibited serotonin reuptake 30 times more than fluoxetine"
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"Although vilazodones selectivity for serotonin reuptake inhibition relative to norepinephrine or dopamine reuptake inhibition is comparable to that of the SSRI fluoxetine, its potency for serotonin reuptake inhibition is 30-fold greater."
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"Results: Vilazodone inhibited serotonin reuptake into rat brain synaptosomes with an IC50 of 0.2 nM, which was 30-fold more potent than that of fluoxetine (IC50=6 nM)."
http://www.sec.gov/Archives/edgar/data/716646/000095012310052757/b81084exv99w6.htm
Refer to:
Kehne JH, Bartoszyk GD, Greiner HE, et al. In vitro characterization of vilazodone as a dual-acting serotonin reuptake receptor and 5-HT1A receptor partial agonist. Poster presented at: 65th Annual Meeting of the Society of Biological Psychiatry Meeting; May 2010; New Orleans, LA.
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Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1072031
URL: http://www.dr-bob.org/babble/20140914/msgs/1072082.html