Re: TRK-b agonists for BDNF knockouts

Posted by linkadge on September 15, 2014, at 17:56:18

In reply to Re: BDNF gene predicts the response to ketamine » linkadge, posted by SLS on September 14, 2014, at 16:32:56

Hi SLS,
I know that the antidepressant effect of certain AD's requires the enhancement of BDNF production or binding or the like.
I know that BDNF binds to the trk-b receptor. Certain agents (i.e. amitriptyline) are direct trk-b agonists. In other words, they mimic the effects of BDNF in the absence of BDNF.
I wonder if trk-b agonists might benefit individuals with the low functioning version of the BDNF gene.
Linakdge

Thread

BDNF gene predicts the response to ketamine SLS 9/14/14
Re: BDNF gene predicts the response to ketamine linkadge 9/14/14
Re: BDNF gene predicts the response to ketamine Lamdage22 9/14/14
Re: BDNF gene predicts the response to ketamine » linkadge SLS 9/14/14
Re: BDNF gene predicts the response to ketamine » SLS Phillipa 9/14/14
Re: BDNF gene predicts the response to ketamine » Phillipa SLS 9/14/14
Re: BDNF gene predicts the response to ketamine » SLS Phillipa 9/14/14
Re: BDNF gene predicts the response to ketamine Lamdage22 9/14/14
Re: TRK-b agonists for BDNF knockouts linkadge 9/15/14
Re: TRK-b agonists for BDNF knockouts SLS 9/15/14
Re: TRK-b agonists for BDNF knockouts linkadge 9/15/14
Re: TRK-b agonists for BDNF knockouts linkadge 9/15/14

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