Posted by SLS on September 14, 2014, at 16:32:56
In reply to Re: BDNF gene predicts the response to ketamine, posted by linkadge on September 14, 2014, at 13:04:13
Hi Linkadge.
> Hi SLS,
>
> When you say:
>
> "People who have MM won't respond at all."
>
> Is this established or just a hypothesis of the study?
>
> Thanks,
>
> LinkadgeIt is a consistent observation in both human and animal studies that VV is more likely to respond to ketamine than either VM or MM. MM is relatively rare.
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http://bipolarnews.org/?p=2318
"Depressed patients with the better functioning Val66Val allele of BDNF respond best to ketamine, those with the intermediate functioning Val66Met allele respond less well, and those with the poorest functioning Met66Met allele virtually do not respond at all."
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* The details of my explanation regarding the genetics involved with BDNF were in error. There are three different alleles for the BDNF gene, not two. An individual will have a combination of any two alleles; one from each parent. If either of these alleles contains the M (Met) domain, BDNF activity will be reduced.
BDNF gene alleles:
VV = Val66Val
VM = Val66Met
MM = Met66MetVal = valine
Met = methionineMy guess is that someone who is homozygous for the MM allelle will be very resistant to ketamine treatment. If cognitive impairment is an index of BDNF genotype (Met load), I probably will not respond to ketamine.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1071129
URL: http://www.dr-bob.org/babble/20140914/msgs/1071139.html