Posted by SLS on August 19, 2014, at 7:48:11
In reply to Re: Sertraline immediately eliminated suicide thoughts, posted by Lamdage22 on August 19, 2014, at 5:51:59
> I don't think i abandoned sertraline prematurely. And i wonder what other effects of Sertraline may have caused me to feel better. Sigma 1 or BDNF?
I've read that the probability of someone responding to antidepressants is linked to the pretreatment blood level of BDNF. Higher BDNF levels indicate better response to SSRIs, even though they are not necessarily linked to initial severity of depression. I don't know if sertraline has a direct affect on BDNF production.
Have you tried fluvoxamine? It is the most potent of the SSRIs with respect to activity at the sigma-1 receptor. Fluvoxamine, but not sertraline, potentiated nerve-growth factor (NGF)-induced neurite outgrowth in PC12 cells.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1069951
URL: http://www.dr-bob.org/babble/20140815/msgs/1069994.html