Posted by LostBoyinNC45 on August 4, 2014, at 10:45:19
Roux Y Gastric bypass surgery for obesity creates hormonal and neurotransmitter changes which decrease your desire to eat as much. Some of these changes include an increase in extracellular dopamine, especially in the striatum part of the brain. This change the surgery creates has to do with the pleasure/reward part of the brain, as eating creates a release of dopamine in the brain. This bariatric surgery also decreases dopamine type 2 receptor availability.
Im speculating this bariatric surgery may be adjunctive to anti-depressants in treatment resistant mood disorders in those who have had good to excellent responses to dopaminergic drugs such as MAOIs like Parnate, to amphetamines like Ritalin and to parkinson drugs.
"CONCLUSION:
The decreases in DA D2 receptor availability after RYGB and VSG most likely reflect increases in extracellular dopamine levels. Enhanced dopaminergic neurotransmission may contribute to improved eating behavior (e.g. reduced hunger and improved satiety) following these bariatric procedures."
Eating too much over time evidently overloads your dopaminergic system and your ability to feel pleasure may decrease over time...possibly a mechanism in depression?
Most bariatric surgery candidates have depression, some severe, prior to major weight loss. Im speculating that some of that may have to do with inability to feel pleasure or reward as much, do to the complex interaction of insulin resistance, lepin, dopamine, etc.
Eric AKA "LostBoyinNC"
poster:LostBoyinNC45
thread:1069206
URL: http://www.dr-bob.org/babble/20140717/msgs/1069206.html