Posted by vincent_QC on August 8, 2014, at 18:37:14
In reply to Gastric bypass decreases dopamine T2 receptor, posted by LostBoyinNC45 on August 4, 2014, at 10:45:19
> Roux Y Gastric bypass surgery for obesity creates hormonal and neurotransmitter changes which decrease your desire to eat as much. Some of these changes include an increase in extracellular dopamine, especially in the striatum part of the brain. This change the surgery creates has to do with the pleasure/reward part of the brain, as eating creates a release of dopamine in the brain. This bariatric surgery also decreases dopamine type 2 receptor availability.
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> Im speculating this bariatric surgery may be adjunctive to anti-depressants in treatment resistant mood disorders in those who have had good to excellent responses to dopaminergic drugs such as MAOIs like Parnate, to amphetamines like Ritalin and to parkinson drugs.
>
> http://yourbrainonporn.com/decreased-dopamine-type-2-receptor-availability-after-bariatric-surgery-preliminary-findings-2010
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> "CONCLUSION:
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> The decreases in DA D2 receptor availability after RYGB and VSG most likely reflect increases in extracellular dopamine levels. Enhanced dopaminergic neurotransmission may contribute to improved eating behavior (e.g. reduced hunger and improved satiety) following these bariatric procedures."
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> Eating too much over time evidently overloads your dopaminergic system and your ability to feel pleasure may decrease over time...possibly a mechanism in depression?
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> Most bariatric surgery candidates have depression, some severe, prior to major weight loss. Im speculating that some of that may have to do with inability to feel pleasure or reward as much, do to the complex interaction of insulin resistance, lepin, dopamine, etc.
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> Eric AKA "LostBoyinNC"
Look good on paper but in real life that's another story!I had a gastric by-pass, almost the same type of the roux en Y... Not the small pounch stomach but they by-pass almost 6 meters of intestine...so malabsorption is the mechanism behind the weight loose...
I had it 13 years ago. I lost almost 65% of my initial weight so went from 450 pounds to 170... Even lower 150 pounds in 2011...
Before I start having bowel problems in 2011, I was able to eat all the food I want even after the gastric by-pass, it never reduce my hunger and I always need to eat... Like before the surgery... So I don't know why they can conclude that the gastric surgery can reduce the hunger...
Ok, I was on diet almost all the time before I had that surgery. Even as a kid I was going to weight watcher with my mom, was exercising and never was able to loose weight a lot. Only high protein diet low in carbs worked to loose a lot of weight but in short term period...
I never had depression or the level of anxiety I have right now before that surgery. I had only social phobia and minor panic attacks only when I had a public speech to do...
I tried the Nardil and find it effective but had too much orthostaric hypotension even if I was taking low dose of Florinef with it. Had very bad reaction to the Parnate who almost kill me without eating foods to avoid...
I always react badly to meds who work on dopamine. Ritalin trigger major panic attacks and same with the Mirapex drug... But I also react badly to antipsychotic meds... So my anxiety disorders are probably not related to the dopamine...
I felt a lot better mentally and physically before that surgery! 1 000 000 better... I had a normal life, had a work, driving my car, had friends to get out... And physically I was very strong and resistant!!! Never tired even if I had sleep apnea... I had a very physical work as a cook in a big hotel restaurant, working sometimes up to 12 hours a day... Was resistant and very active physically! Doing long bike ride of 4 days in a row was usual for me.
Now, I can't even walk for 5 minutes, all my body hurt and I have no strength at all. Mentally I feel drained all the time and can't concentrate on things like tv or computer for more than 20-30 minutes... After that I feel like my brain is on fire and have panic attacks...
I can't even get out of my house right now, I have agoraphobia and I'm housebound. I can't drive and even can't go in a car as a passenger for more than 5 minutes. Forget about going on the highway, as a passenger I can't... I have heart problems (dysautonomia and pots), have bowel problems (had 2 complete bowel obstructions and 1 bile duck canal obstruction) as well, I lost all my muscles and I'm very weak physically. I feel tired all the time even after a good night of sleep, who don't happen often. I have around 5 to 10 panic attacks a day, have legs pain, chronic chest pain, depersonalization, insomnia, TMJ facial pain, chronic tension headache.. Just to name a few problems...
I also develop med sensitivities so can't even stabilize my anxiety with an antidepressant anymore. I'm highly addicted to the benzodiazepine, I'm tolerant to their effect, I'm on 7 mg day of Klonopin and it's doing nothing at all. Im allowed to take 1 mg of Xanax when I have too many panic attacks a day and they don't want to stop... I'm taking a beta blocker med to reduce my crazy fast heart rate (metoprolol 75 mg day)...
Overall, I feel very weak, I'm hungry all the time, physically I'm so weak that I can't even walk and certainly not doing exercise cause of the crazy fast heart rate and dizziness, I have 0 quality of life, I have 0 social life, I sit on the couch all day long and almost wait to die... That's my life...
I have big regrets about that surgery... It's a quick fix to loose weight, but in the long term they don't change your food cravings and bad eating habit...
Seem weird to write that but I felt a lot better at 450 pounds than at 170 pounds. I was a good person with a very funny personality, I mean I was laughing all the time and had fun. I was anxious about the way I look and the fact that I was fat and I was shy and basically had social phobia, but I was totally different back then.
Now, I have no personality, I don't laught often, very negative, don't like the way I look, continue to feel like I'm not socially acceptable and that everyone judge me and the way I look...
So overall I don't see the link between the change in dopamine system after the surgery and the anti depressive effect. It don't refuse the hunger feeling or reduce the amount if food the person will eat, It didn't seem to be link to the insulin release also cause my blood glucose level is very good all the time even after I eat a lot of sugar...
Dopamine is probably not the main culprit problem ebbing depression or anxiety for sure. I don't think science even know why depression or anxiety happen...
poster:vincent_QC
thread:1069206
URL: http://www.dr-bob.org/babble/20140717/msgs/1069426.html