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Micromedex Warning on Aptiom But With Benefit

Posted by LouisianaSportsman on May 5, 2014, at 23:46:19

In reply to Yep, Micromedex: Warning on Brintellix + Dexedrine » rjlockhart37, posted by LouisianaSportsman on May 5, 2014, at 22:54:19

Eslicarbazepine is a CYP34A inducer so it would reduce my Latuda requiring me to up the dosage--

Based on this study:

RESULTS: ESL significantly decreased the systemic exposure to both ethinylestradiol and levonorgestrel. GMR (90%CI) for AUC0-24 of ethinylestradiol were 68% (64%; 71%) following 1200mg ESL and 75% (71%; 79%) following 800mg ESL. GMR (90%CI) for AUC0-24 of levonorgestrel were 76% (68%; 86%) following 1200mg ESL and 89% (82%; 97%) following 800mg ESL.

I would need about ~25% increase of Latuda which would be 75mg., so there are 80mg. tablets which I have handled perfectly fine in the past. No biggie.

But, Aptiom is a CYP2C19 inhibitor which means it would increase my Brintellix, which is perfectly fine with me, as I was thinking about moving up my dose anyway, this sounds like a perfect way to do it. -- this is the Benefit as discussed in the Subject.


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poster:LouisianaSportsman thread:1065262
URL: http://www.dr-bob.org/babble/20140419/msgs/1065288.html