Posted by Dispossessed on March 4, 2014, at 13:58:24
In reply to Re: Sudden sensitivity to SSRIs/side effects?, posted by LouisianaSportsman on March 3, 2014, at 21:02:20
> I think the Latuda (lurasidone) would be an excellent choice to try next regardless of the "no AP without AD" philosophy you have, Eric. The only 5-ht activity that isn't good is the 5-HT2A antagonism which is balanced out by 5-HT1a partial agonism and perhaps the benefits of 5-HT7 antagonism. Lurasidone also has less of a cognitive imprint with its D2 receptor blockade pattern comparatively to other AAPs and actually has benefits (5-HT7).
>
> It's too bad Viibyrd won't hit the market until the later part of 2014 and Brintillex is unknown. I am on my first day of Brintillex, Dispossessed, it's a shame the UK market is so far behind (via benzo prescribing too, I see).I would look into it, but it hasn't been given EU approval as well. Even if it was, I would have a hard time getting a GP/psychiatrist to prescribe it to me. In the UK doctors tend to prescribe drugs that are off-patent to save the NHS money - which is why there was a period where people were being taken off escitalopram to be placed on citalopram as the latter was generic whereas the former was not.
> Scott, BRAVO! for mentioning Luvox, a OCD SSRI posterboy and clomipramine, the heavy-hitter of OCD medications. The poster does not need to discredit trying these if at all possible.
>I tried them both - unfortunately clomipramine had a lot of intolerable side effects, whereas fluvoxamine didn't touch the anxiety/sense of dread, and the jaw clenching/restless legs were as bad as ever. This was at 50mg. I could have gone higher, but the jaw clenching appears to be serotonin, and therefore dose-related.
poster:Dispossessed
thread:1061454
URL: http://www.dr-bob.org/babble/20140214/msgs/1061834.html