Posted by LouisianaSportsman on March 3, 2014, at 20:04:51
In reply to Re: Brintellix Trial 10mg. @Eric, Scott, Lamdage22 » LouisianaSportsman, posted by SLS on March 3, 2014, at 19:45:05
> My reaction to asenapine was very similar to lurasidone. I felt better for a few days, and then began to deteriorate. I felt worse on it than off it. I attribute this to NE alpha-2a receptor antagonism. Both drugs do this. So do mirtazapine and idazoxan. All four of these drugs exacerbate my depression. I can't help but to conclude that NE alpha-2a antagonism is to blame. In the cases of lurasidone and asenapine, I think the 5-HT7 receptor blockade produced the initial improvement, only to be opposed later by the emergence of sufficient NE alpha-2 blockade to disrupt my mood. I think it was a matter of time dependence rather than dosage dependence.
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> I am very anxious to see how people do on Brintellix. Eric (Phiddipus) has chosen to describe his response to Brintellix using words that I like to hear.
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> - ScottSo you're hoping that the 5-HT7 boost without the malicious NE alpha-2a antagonism will be so b*d*ss enough to be an alternative to Parnate? I guess so if aripiprazole has been the most effective for you so far. How well do you do on run-of-the-mill SSRIs? I'm curious if it'll have a reuptake inhibition effect similar to that of a Cymbalta (duloxetine) SNRI type or your traditional SSRI, Prozac (fluoxetine) type. How well do you do on -xetine's?
If you do OK enough and the 5-HT7 antagonism is significant enough, it might overcome the activity of MAOI; thus it would be a wise switch.
Yeah, obvious Eric's input was in my subconscious when I brought this up at the PDOC today. I also liked his input, I am hoping for a similar result!
poster:LouisianaSportsman
thread:1061746
URL: http://www.dr-bob.org/babble/20140214/msgs/1061780.html