Posted by SLS on March 3, 2014, at 19:45:05
In reply to Re: Brintellix Trial 10mg. @Eric, Scott, Lamdage22, posted by LouisianaSportsman on March 3, 2014, at 19:18:48
> > Good luck!
> >
> >
> > - Scott
> Thanks!
>
> Scott, are you on asenapine now?
>
> I'll let you know if this Brintellix is worth the Parnate switch or not.Thanks - big time.
> I let you down on the lurasidone, so be weary of my advice, lol.
Silly!
My reaction to asenapine was very similar to lurasidone. I felt better for a few days, and then began to deteriorate. I felt worse on it than off it. I attribute this to NE alpha-2a receptor antagonism. Both drugs do this. So do mirtazapine and idazoxan. All four of these drugs exacerbate my depression. I can't help but to conclude that NE alpha-2a antagonism is to blame. In the cases of lurasidone and asenapine, I think the 5-HT7 receptor blockade produced the initial improvement, only to be opposed later by the emergence of sufficient NE alpha-2 blockade to disrupt my mood. I think it was a matter of time dependence rather than dosage dependence.
I am very anxious to see how people do on Brintellix. Eric (Phiddipus) has chosen to describe his response to Brintellix using words that I like to hear.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1061746
URL: http://www.dr-bob.org/babble/20140214/msgs/1061777.html