Posted by SLS on February 22, 2014, at 16:31:22
In reply to Re: Serotonin 5-HT7 receptor antagonism and depression, posted by jono_in_adelaide on February 22, 2014, at 7:08:31
> I think risperidone is also a 5HT7 antagonist, no?
Yes. So much so, that it is actually an irreversible inverse agonist. An inverse agonist not only blocks the receptor from doing its job, it fools it into doing the *opposite* of what it was designed to do. For example, if a receptor normally depolarizes the cell membrane when stimulated, an inverse agonist will cause the receptor to hyperpolarize the cell membrane.
> I found 1mg at night very helpfull in depression and anxietyThat's great!
Do you experience an improvement in depression and anxiety throughout the day?
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1060890
URL: http://www.dr-bob.org/babble/20140214/msgs/1061069.html