Serotonin 5-HT7 receptor antagonism and depression

Posted by SLS on February 19, 2014, at 23:15:39

There is an increasing focus on the serotonin 5-HT7 receptor and its involvement in the etiology and treatment of depression. Among the drugs that act as antagonists at this receptor are lurasidone (Latuda), asenapine (Saphris), aripiprazole (Abilify), vortioxetine (Brintellix), levomilnacipran (Fetzima), and amisulpride (Solian). I think it is worth investigating this subject further.

Other 5-HT7 antagonists according to Wiki:
Amisulpride
Amitriptyline
Amoxapine
Clomipramine
Clozapine
Cyproheptadine
EGIS-12233
Fluphenazine
Fluperlapine
ICI 169,369
Imipramine
Ketanserin
Loxapine
Lurasidone
LY-215,840
Maprotiline
Mesulergine
Methysergide
Mianserin
Olanzapine
Ritanserin
SB-258,719[24][25][26]
SB-258,741[26]
SB-269,970 (highly 5-HT7 selective)[27]
SB-656,104-A[28]
SB-691,673[24]
Sertindole
Spiperone
Sulpiride
Tenilapine
TFMPP
Vortioxetine
Trifluoperazine
Ziprasidone
Zotepine

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

Thread

Serotonin 5-HT7 receptor antagonism and depression SLS 2/19/14
Re: Serotonin 5-HT7 receptor antagonism and depression » SLS Phillipa 2/20/14
Re: Serotonin 5-HT7 receptor antagonism and depression » Phillipa SLS 2/20/14
Re: Serotonin 5-HT7 receptor antagonism and depression jono_in_adelaide 2/22/14
Re: Serotonin 5-HT7 receptor antagonism and depression » jono_in_adelaide SLS 2/22/14
Re: Serotonin 5-HT7 receptor antagonism and depression bleauberry 2/22/14
Re: Serotonin 5-HT7 receptor antagonism and depression jono_in_adelaide 2/22/14
Important correction: SLS 2/23/14

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