Posted by Legm82 on November 6, 2013, at 21:52:53
In reply to Re: trimipramine vs remeron, posted by linkadge on November 2, 2013, at 18:02:36
> I think that trimipramine would be a more effective as a sleep aid. It has histamine and 5-ht2 angatonism, but it lacks noradrenergic enhancement, which might be better for sleep. It blocks a1 adrenergic receptors which will may reduce alertness.
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> In addition it has some d2 antagonism which could reduce agitation. I think trimipramine probably has some ion channel inhibition (calcium channel blockade?) which can help sleep.
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> Linkadge
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>Hello Linkadge
It is very interesting what you say about the receptors involved with Trimipramine and compare the two drugs.
Usually Remeron (mirtazapine) is well known as a first choice sleep aid.
I wonder if Trimipramine can help with sleep "ONSET" and "Manteinance" as well as Remeron.
Theorically it should work, but are you sure it would help? .. why isnt trimipramine advertised as much as Remeron for sleep problems?
Thanks for your reply.
Best regards,
Luis.
poster:Legm82
thread:1053603
URL: http://www.dr-bob.org/babble/20131025/msgs/1053912.html