Posted by linkadge on November 2, 2013, at 18:02:36
In reply to trimipramine vs remeron, posted by jpa on November 2, 2013, at 14:02:17
I think that trimipramine would be a more effective as a sleep aid. It has histamine and 5-ht2 angatonism, but it lacks noradrenergic enhancement, which might be better for sleep. It blocks a1 adrenergic receptors which will may reduce alertness.
In addition it has some d2 antagonism which could reduce agitation. I think trimipramine probably has some ion channel inhibition (calcium channel blockade?) which can help sleep.
Linkadge
poster:linkadge
thread:1053603
URL: http://www.dr-bob.org/babble/20131025/msgs/1053623.html