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Re: Irving Kirsch, placebos and antidepressants » linkadge

Posted by SLS on October 22, 2013, at 6:34:23

In reply to Re: Irving Kirsch, placebos and antidepressants, posted by linkadge on October 19, 2013, at 17:16:23

> Dopamine increases the motivation to act. Serotonin (ie. SSRIs) counteracts this. SSRIS decrease the motivation and drive to act or achieve things.

Is this true of SSRIs even when they produce a robust antidepressant response, or is this associated only with non-response? I don't doubt that SSRI-induced apathy and amotivation are acute effects, but what happens after receptor desensitization occurs? Wouldn't these unwanted effects dissipate?

I don't know, of course.


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URL: http://www.dr-bob.org/babble/20130930/msgs/1052758.html