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Parnate (tranylcypromine) dose

Posted by Snell on October 6, 2013, at 14:17:34

Hello everyone. I have been having a disagreement with my pdoc over the appropriate dose of Parnate--yes, it's an MAOI--for me. (I began it textbook style, with a washout period--that was awful--I stay away from tyramine, etc.)

On 20mg/d, I have had some remission of symptoms. I still feel, however, social isolation, anergia, low mood, and sleep disturbances. (The sleep disturbances may be a result of the Parnate.) My blood pressure is normal. My health, otherwise, is good.

I have been taking the Parnate since September 1. I would like to try a higher dose. My pdoc is *strongly* opposed to this. The literature that supports a 20 mg/d dose all comes from the manufacturers or sites such as RxList and Drugs.com. The research literature, however, supports raising the Parnate to sixty (60) to eighty (80) mg/day. Several articles have recommended a dose of 1 mg/kg. I weigh 102 kg, so obviously that's a dose of 100mg/day.

Some pdocs raise the Parnate to 150 to 200 mg/day in nonresponders. I am not asking for this. I am concerned that I am taking a subtherapeutic dose. Any advice or reactions?


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poster:Snell thread:1051793
URL: http://www.dr-bob.org/babble/20130930/msgs/1051793.html