Posted by yearism on September 23, 2013, at 16:57:51
In reply to Re: Agomelatine and Tranylcypromine for OCD » linkadge, posted by Franz on March 25, 2011, at 12:27:28
> > A 5-ht2c antagonist could theoretically increase OCD like behavior. Although fluoxetine is a 5-ht2c antagonist, it is also a SSRI. In other words, the net effect is 5-h5t2c agonism (I believe). Most SSRIs are 5-ht2c agonists, and there are case reports of drugs like cyproheptadine (combined 5-ht2a/c antagonists) causing relapse in OCD patients on SSRIs. Also, there are reports of 5-ht2a/c agonists like tryptamine, mescaline etc. rapidly improving OCD symptoms.
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> > Another (theoretical) possiblility is potentiation of 5-ht1a mediated neurotransmission and possible serotonin syndrome. If you haven't experienced this yet, the risk seems low. However, since certain sertonergic antagonists (like antipsychotics) can increase 5-ht1a mediated effects when combined with SSRIs, the risk with combination with agomelatine is a possbililty.
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> > You might find that simply taking periodic breaks from the agomelatine (or reducing the dose) is sufficent to regain the anti-ocd effect.
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> > Linkadge
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> I am confused. Why use agomelatine (which I am trying with some problems like short sleep, nightmares, etc.) if fluoxetine is also a 5-ht2c antagonist?. Is it because of the side effects?
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> Fluoxetine looks like escitalopram+agomelatine and much cheaper. Why are we taking newer and expensive drugs?.
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> Thanksthis is all wrong.mcpp which is a typical 5ht2c agonists is used in challenging studies for ocd.ssris dont show an agonist effect on serotonergic receptors.conversely,it has antagonistic effects on ser. receptors in long-term.serotonergic agonism doesnt always mean good clinical results.please read to learn the reliable sources in a careful way!
poster:yearism
thread:980414
URL: http://www.dr-bob.org/babble/20130828/msgs/1051198.html