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Re: Agomelatine and Tranylcypromine for OCD

Posted by sk85 on April 3, 2011, at 7:18:11

In reply to Re: Agomelatine and Tranylcypromine for OCD, posted by Dr.Fischer-Terworth on April 3, 2011, at 2:38:20

>
> Hallo,
>
> two years ago I noticed by incident that magnesium (300mg) had some beneficial effects on OCD symptoms. First I guessed this could be
> imagnination but it is in fact the case because 600 mg Magnesium can reduce compulsive urges
> at least to a certain amount.
> Now I recognized that adding Magnesium 600 mg to the regimen Tranylcypromine 40 mg+agomelatine 25 mg, it partially may compensate for
> the (potential) anti-OCD-effects of agomelatine,
> which I attribute to the 5-HT-2c antagonism.
>
> It is known that Magnesium it works for depression and it is supposed to be acting via serotonergic pathways although it seems to be unknown which way.As Mg is also a NMDA-antagonist and the NMDA-antagonist Memantine has been used as an augmenter of SSRI in OCD patients being partial responders to SSRI, it might also act that way. Glutamatergic dysfunction (overactivity
> in the Thalamus) is associated with OCD (shown at least in children and adolescents) and NMDA-antagonism could also facilitate pro-GABA-ergic effects reducing anxiety.
>
> Does anyone have information about magnesiums psychopharmacological profile of action?
>
> Thank you very much for your comments!
>
> Best wishes,Christian

I take magnesium 600 mg daily with zinc as a general supplement. But I haven't noticed it being any help for OCD. I have also taken memantine and aswell did not find it helpful. It just might be that OCD can have various different underlying neurochemical forms which all lead to the same end result i.e. OCD symptoms.

-Ikaros


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