Posted by SLS on May 19, 2013, at 7:07:26
In reply to Re: question for SLS re: minocycline, posted by g_g_g_unit on May 19, 2013, at 6:45:59
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> > > do you believe it has the potential to show anti-depressant efficacy when NOT used in conjunction with lamitrogine
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> > Yes. Minocyline does a bunch of stuff besides reducing glutamate activity. It is hard to know what properties are important in the treatment of depression. Besides, its antiglutamatergic properties are substantial at multiple sites, even in the absence of lamotrigine. For OCD, one might speculate that combining memantine with minocycline would have a synergistic effect.
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> > I am not familiar with any psychotropic effects that Augmentin might have. The cool thing is that minocycline is used to treat Lyme Disease. So, if that is a concern of yours, you would be attacking your condition(s) from multiple angles.
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> Thanks for your response. I've found a GP who's willing to trial an antiobiotic. One paper I came across suggested Augmentin has similar glutamate-modulating properties, but perhaps Minocycline would be a better place to start given its proven efficacy in treating depression.
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> Just one other point you may have missed in my original post - has Minocycline had any impact (beneficial or otherwise) on your anxiety, pending that's a fact of your condition?I don't know whether or not minocycline works as an anxiolytic. I wouldn't be able to tell. I have taken care of the bulk of my anxiety through CBT and desensitization. My social anxiety used to be paralyzing. I would not characterize minocyclne as being pro-social as is Nardil. I'm sure you are aware that anxiety can be a feature of depression, even in the absence of an anxiety disorder. In those days when my social anxiety was still substantial, it would totally evaporate when I responded to tricyclics or MAOIs.
MI really sucks.
I hope you find something soon.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1043862
URL: http://www.dr-bob.org/babble/20130501/msgs/1043907.html