Posted by bleauberry on March 3, 2013, at 12:25:53
In reply to Can antipsychotics+ antidepressants work together?, posted by PrettyLady on February 28, 2013, at 19:57:17
The agonism and antagonism stuff....it just aint that simple. For example, block a receptor and what might it do?....send signals to feedback loops to make more because something's blocked! So instead of blocking and getting less of something, it can actually result in more of something.
Studies with antipsychotics and antidepressants usually show synergistic changes of the levels of neurotransmitters in the brain. Prozac and zyprexa is a great combo for that, increasing all three neuros a by a lot (several hundred percent). Zyprexa and zoloft increased dopamine but not serotonin or NE. The different combos all behave differently.
The theory stuff is interesting and it's easy to get into it because we are depressed and nothing else is interesting except studying stuff about our own suffering. But theory doesn't help. Trying stuff does. You already discovered that yourself, before you even knew that AD+AP might be better than AD alone.
That said, I personally think seroquel is a poor choice. It is basically just one of the world's most powerful anti-histamines. Its other mechanisms are less in comparison. It displays a very high poopout rate, here at pbabble anyway. People that have been on APs for a long time and still getting benefit from them, that usually is either zyprexa or abilify, rarely seroquel.
poster:bleauberry
thread:1039120
URL: http://www.dr-bob.org/babble/20130222/msgs/1039442.html