Posted by tensor on January 20, 2013, at 6:34:40
In reply to Re: Clomipramine - Augmentation options? » tensor, posted by SLS on January 20, 2013, at 6:24:22
> > I know fluvoxamine is used in combination with clomipramine, it makes clomipramine more serotonergic due to a metabolic change.
>
> Hmm. Interesting. I didn't know that. You are right, of course.
>
> Which metabolic route (enzyme) is responsible for this? I know that CYP3A4 is inhibited by fluvoxamine, but that should not affect a TCA, should it? Is clomipramine different than the other TCAs in this regard?Fluvoxamine inhibits CYP1A2. Which is the enzyme breaking down clomipramine to desmethyl-clomipramine (which is a strong NE reuptake inhibitor.) This results in higher clomipramine levels and stronger serotonin action.
/tensor
> I hope you slept well.
Thanks, I did :-)
poster:tensor
thread:1035819
URL: http://www.dr-bob.org/babble/20130112/msgs/1035846.html