Posted by SLS on January 3, 2013, at 7:19:23
In reply to SLS you've tried lithium and nardil right?, posted by gilmourr on January 3, 2013, at 3:44:01
> Right now I'm doing lamictal + zoloft + maybe 1-2 mg of abilify later on for major depression and panic.
Good luck with that. I would not abandon the Zoloft until you also try adding nortriptyline or desipramine. Tricyclic antidepressants (TCA) have long been ascribed anti-panic properties, especially imipramine
> If this doesn't work I'm going to probably try nardil again (which would be in 3 months if this fails).
3 months is an interesting choice. Some of my doctors have found that a 3-month holiday from Nardil after its pooping-out allows for a return of a robust response when the Nardil is restarted.
> Reason I might give it a shot is because I think being 4 times over the limit of B6 screwed with it and possibly the amlodipine interaction when I started it might've messed it up.
I guess it's possible. I am aware of the Nardil - B6 interaction. However, I have yet to actually witness someone lose an antidepressant effect because of it. I would take a rechallenge to confirm such a thing. That said, I agree with you that it makes sense not to take megadoses of B6
> ANYWAYS, question. On nardil the worst symptom I have is shivers/cold intolerance.
For how long did you experience these things? How many weeks did you remain on Nardil once they first appeared. I ask this because I have experienced this transiently with both Nardil and Parnate. I would actually continue to increase the dosage despite the appearance of this phenomenon. You might be caught "in-between" response and relapse.
> - Do you think these shivers are caused by norepinephrine or a metabolite of nardil? Cymbalta and Parnate made me extremely cold.
I think it makes sense to have your thyroid checked.
> And parnate is more NE based I believe.
I agree, although a serotonin syndrome drug interaction is no less a risk with Parnate than it is with Nardil.
> - Would lithium handle this?Taking low-dose lithium wouldn't hurt to try as an augmenter (300 - 600 mg/day).
> I heard it converts Norepinephrine to serotonin.
Lithium does not convert norepinephine into serotonin.
> If there's a better balance it would get rid of the coldness and help with any insomnia + give me the great efficacy of nardil.
Lithium does a great many things in the brain, one of which is an increase in the release of serotonin. So, I guess you could theorize that there might be a better balance. Your reasons for taking lithium are good ones.
> Thoughts?
:-)
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1034303
URL: http://www.dr-bob.org/babble/20121231/msgs/1034544.html