Posted by Emme_V2 on January 2, 2013, at 19:22:38
In reply to Re: More evidence of inflammation and depression. » Emme_V2, posted by SLS on January 2, 2013, at 17:46:40
> Hi Emme_V2
>
> When you have a chance, can you excise and quote the passages that you believe are proof of directionality?
>
> I still don't see it.
>
>
> - Scott
>Sure. I'm afraid it might take me a week or so before I have a chance to sit down and fully digest the content, and you will probably beat me to it. :)
But it's really not my conclusions. (If only I were that smart!) Leonard and Maes state in their abstract:
"It is concluded that depression may be the consequence of a complex interplay between CMI activation and inflammation and their sequels/concomitants which all together cause neuroprogression that further shapes the depression phenotype. Future research should employ high throughput technologies to collect genetic and gene expression and protein data from patients with depression and analyze these data by means of systems biology methods to define the dynamic interactions between the different cell signaling networks and O&NS pathways that cause depression."
And they do describe a sequence of processes and what they think needs to come next. Note that they use "may." This is a different field of science than mine, so I'll probably get a bit lost in the details without logging some study time. Since the authors worked through the info and got the thing published in a peer-reviewed journal, I figure that may have a case. Of course they may be totally wrong as well, but that will hopefully get sorted out as the science progresses. And of course, the cause of depression for one person may be completely than the cause for another person, so your idea that depression can cause in inflammatory response may hold true as well.
poster:Emme_V2
thread:1034419
URL: http://www.dr-bob.org/babble/20121231/msgs/1034495.html