Posted by Emme_V2 on January 2, 2013, at 16:59:00
In reply to More evidence of inflammation and depression., posted by SLS on January 2, 2013, at 7:54:16
> I don't subscribe to the inflammation causes depression school of thought. In my mind, stress comes first, depression comes second, and inflammation comes third. Of course this is only a guess. At most, there might be a convergence. However, there are too many different non-inflammatory biomarkers associated with depression to ignore, including genetic.
Below are a couple of articles that can support the "inflammation leading to depression" directionality. (I've skimmed them quickly, but I haven't read them in detail.)
I'm sure researchers will gather more information before things are sorted out one way or the other. And of course, there are probably a number of etiologies for depression, including genetic contributions. Who knows, perhaps stress leads to inflammatory response, which helps trigger depression for Person A, while a different pathway produces depression for Person B.
http://www.ncbi.nlm.nih.gov/pubmed/22197082
http://stevebmd.files.wordpress.com/2011/04/cytokines-sing-the-blues2006.pdf
poster:Emme_V2
thread:1034419
URL: http://www.dr-bob.org/babble/20121231/msgs/1034477.html