Posted by larryhoover on December 27, 2012, at 16:59:24
In reply to Re: Bifidobacteria reduce depression, posted by Trotter on December 27, 2012, at 16:09:53
> I'm not sure you will ever have a proper human trial to see if high fat feeding causes depression. It would be cruel.
Observational studies are possible, but nobody ever properly conducted a study that controlled carbs while controlling fat. I found a bunch of improper studies, but they lumped refined carbs in with fried foods, and red meat. Hopelessly confounded. But depression was associated with those inflammatory markers, nonetheless. It was the attribution of that marker to fat that was flawed.
The studies I first referenced make clear that the inflammatory markers are not caused by high fat intake, but arise from refined carbs. Recent work has broken the confound.
One of the clearest blood variables associated with depression is high-density lipo-protein. When HDL is low, depression is high. And that is a marker of a high-carb diet. HDL is highest on high-fat diets.
> Please show me a reference to a rodent trial showing a high fat diet reduces depression.
http://www.ncbi.nlm.nih.gov/pubmed/22313665
Honestly, though, I don't put much faith in these rodent studies. We are not rodents. And they did not control for carbs.
Lar
poster:larryhoover
thread:1033371
URL: http://www.dr-bob.org/babble/20121217/msgs/1033993.html